Most Likely Transformations: The mlt Package
نویسنده
چکیده
The mlt package implements maximum likelihood estimation in the class of conditional transformation models. Based on a suitable explicit parameterisation of the unconditional or conditional transformation function using infrastructure from package basefun, we show how one can define, estimate and compare a cascade of increasingly complex transformation models in the maximum likelihood framework. Models for the unconditional or conditional distribution function of any univariate response variable are set-up and estimated in the same computational framework simply by choosing an appropriate transformation function and parameterisation thereof. As it is computationally cheap to evaluate the distribution function, models can be estimated by maximisation of the exact likelihood, especially in the presence of random censoring or truncation. The relatively dense high-level implementation in the R system for statistical computing allows generalisation of many established implementations of linear transformation models, such as the Cox model or other parametric models for the analysis of survival or ordered categorical data, to the more complex situations illustrated in this paper.
منابع مشابه
Ameliorative role of melatonin against cypermethrin or gamma irradiation induced testicular damage in male rats
Background: This work aimed at studying the protective effect of melatonin (MLT) against cypermethrin or γ-radiation induced testicular damage. Material and Methods: Thirty six Male rats were randomly divided into 6 groups. Control group, group treated with MLT (10 mg/Kg b. wt.), group administered cypermethrin (25 mg/ kg. b. wt.), group 4 was exposed to fractionated whole body γ-radiation (th...
متن کاملChronopharmacology of melatonin in mice to maximize the antitumor effect and minimize the rhythm disturbance effect.
The influence of dosing time on the antitumor effect and the rhythm disturbance effect of melatonin (MLT) was investigated in ICR male mice under a light/dark (12:12) cycle. In tumor-bearing mice, the antitumor effect of MLT (1 mg/kg intraperitoneal) was most effective in the dark phase; and the rhythm disturbance effect of MLT on the locomotor activity was more serious in the light phase than ...
متن کاملEffect of exposure to extremely low frequency magnetic fields on melatonin levels in calves is seasonally dependent
The question of health effects of extremely low frequency (50/60 Hz) magnetic fields (ELFMF) has been widely discussed, but the mechanisms of interaction of these fields with biological systems for intensities relevant to human and animal exposure are still under question. The melatonin (MLT) hypothesis suggests that exposure to ELFMF might decrease MLT production thereby promoting cancerogenes...
متن کاملMLT-10 Defines a Family of DUF644 and Proline-rich Repeat Proteins Involved in the Molting Cycle of Caenorhabditis elegans
The molting cycle of nematodes involves the periodic synthesis and removal of a collagen-rich exoskeleton, but the underlying molecular mechanisms are not well understood. Here, we describe the mlt-10 gene of Caenorhabditis elegans, which emerged from a genetic screen for molting-defective mutants sensitized by low cholesterol. MLT-10 defines a large family of nematode-specific proteins compris...
متن کاملTurbulent convection : is 2 D a good proxy of 3 D ?
Several authors have recently carried out 2D simulations of turbulent convection for both solar and massive stars. Fitting the 2D results with the MLT, they obtain that α MLT > 1 specifically, 1.4 ≤ α MLT ≤ 1.8. The authors further suggest that this methodology could be used to calibrate the MLT used in stellar evolutionary codes. We suggest the opposite viewpoint: the 2D results show that MLT ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2017